Month: November 2022

New publication led by Lisa Lombardi shows that editing genes with CRISPR-Cas9 in Candida parapsilosis results in Loss of Heterozygosity (LOH) near the target site. Be careful when evaluating phenotypes of mutants made using CRISPR….https://pubmed.ncbi.nlm.nih.gov/36416551/

Sean Bergin and ex-PhD student Fang Zhao led this study, in collaboration with Tobias Höhl at the Memorial Sloan Kettering Cancer Center, New York and Florent Morio at University Nantes. The paper describes the largest population study of Candida parapsilosis. In addition, we identified an amplification of a flippase gene…