{"id":156,"date":"2022-11-15T12:30:16","date_gmt":"2022-11-15T12:30:16","guid":{"rendered":"http:\/\/gene30070.ucd.ie\/?p=156"},"modified":"2022-11-16T12:00:07","modified_gmt":"2022-11-16T12:00:07","slug":"new-publication-miltefosine-resistance","status":"publish","type":"post","link":"http:\/\/butler.ucd.ie\/index.php\/2022\/11\/15\/new-publication-miltefosine-resistance\/","title":{"rendered":"New publication-miltefosine resistance"},"content":{"rendered":"\n<p>Sean Bergin and ex-PhD student Fang Zhao led this study, in collaboration with Tobias H\u00f6hl at the Memorial Sloan Kettering Cancer Center, New York and Florent Morio at University Nantes. The paper describes the largest population study of <em>Candida parapsilosis<\/em>. In addition, we identified an amplification of a flippase gene <em>RTA3<\/em> that is correlated with resistance to miltefosine, a phosphatidyl choline analogue. <a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01777-22\">Published in mBIO<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1011\" src=\"http:\/\/gene30070.ucd.ie\/wp-content\/uploads\/2022\/11\/mbio.01777-22-f001-1024x1011.gif\" alt=\"\" class=\"wp-image-189\" srcset=\"http:\/\/butler.ucd.ie\/wp-content\/uploads\/2022\/11\/mbio.01777-22-f001-1024x1011.gif 1024w, http:\/\/butler.ucd.ie\/wp-content\/uploads\/2022\/11\/mbio.01777-22-f001-300x296.gif 300w, http:\/\/butler.ucd.ie\/wp-content\/uploads\/2022\/11\/mbio.01777-22-f001-768x758.gif 768w, http:\/\/butler.ucd.ie\/wp-content\/uploads\/2022\/11\/mbio.01777-22-f001-1536x1517.gif 1536w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Sean Bergin and ex-PhD student Fang Zhao led this study, in collaboration with Tobias H\u00f6hl at the Memorial Sloan Kettering Cancer Center, New York and Florent Morio at University Nantes. The paper describes the largest population study of Candida parapsilosis. In addition, we identified an amplification of a flippase gene&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/posts\/156"}],"collection":[{"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/comments?post=156"}],"version-history":[{"count":5,"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/posts\/156\/revisions"}],"predecessor-version":[{"id":195,"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/posts\/156\/revisions\/195"}],"wp:attachment":[{"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/media?parent=156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/categories?post=156"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/butler.ucd.ie\/index.php\/wp-json\/wp\/v2\/tags?post=156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}